New Research Reveals Debate on Adult Neurogenesis

• Karolinska Institutet’s study reveals evidence of adult neurogenesis using modern sequencing and machine-learning.

• The study combines transcriptomics with spatial localisation, rekindling the debate on when neurogenesis stops in adulthood.

• Evidence of neural progenitor cells and young neurons found in the hippocampus, the memory center of adult human brains.

• The study opens the door for regenerative therapies, particularly in ageing individuals suffering from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and other dementias.

• The study identified critical functions of adult-born neurons in the hippocampus, including the ability to distinguish between similar contexts, rewrite memories, and stress resilience.

• Neural circuits in the dentate gyrus of the hippocampus were involved, supporting the idea that adult neurogenesis is a conserved feature in mammals.

• The neurogenesis field is now ready to move on, acknowledging the existence of progenitors.

• The study’s results are not quantitative, but confirm the presence of neuroblast and neural progenitor cells in the adult hippocampus.

Adult Neurogenesis Debate is important topic for Civil service exam (WBCS).

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