New Research on Connexin Proteins and Brain’s Energy Efficiency

• The brain’s energy system, known as neurovascular coupling, responds instantly to sudden bursts of activity.

• The process involves arteries coordinating across surprising distances to prevent lapses in attention or function.

• The brain’s supply network must pitch in, pushing more fuel into the pipeline.

• The process is facilitated by gap junctions, narrow portals that allow neighboring cells to exchange ions and small molecules.

• Two connexin proteins, Cx37 and Cx40, were found to be especially abundant in the arteries and may be responsible for the rapid call to action.

• The study was published in Cell in July.

• The arrangement allows signals to travel along vessel walls to widen upstream arteries, boosting blood flow to active brain areas.

• The findings could help detect vascular problems, test drugs virtually, and guide therapies, especially when paired with artificial intelligence models.

• The study could also help explain mismatches between brain activity and blood flow.

• The findings could help develop drugs to activate connexins and discover how the brain’s 20+ connexin protein types combine into mosaic junctions that fine-tune messages from cell to cell.

Neuroscience Connexin Protein Study is important topic for Civil service exam (WBCS).

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