TTP-associated CoronaVac inactivated COVID-19 vaccine

• A study published in Frontiers of Medicine found an association between the inactivated COVID-19 vaccine CoronaVac and immune thrombotic thrombocytopenic purpura (TTP).
• Two cases of TTP occurred after vaccine administration, indicating a possible correlation between the vaccine and TTP.
• The study also examined TTP incidence in the Nanjing area of China, suggesting a possible correlation between COVID-19 vaccination and TTP.
• The study found an increase in TTP incidence from 2019 to 2022, possibly related to COVID-19 vaccination.
• The increase in TTP cases could be associated with the vaccines, but a direct causal link is not established.
• The study explores potential mechanisms by which COVID-19 vaccines could trigger TTP, focusing on the autoimmune response that may cross-react with ADAMTS13, leading to its deficiency and subsequent TTP development.