• Home /Exam Details (QP Included) / MicroRNA Discovery and Gene Regulation
  • MicroRNA Discovery and Gene Regulation
    Posted on October 8th, 2024 in Exam Details (QP Included)

    MicroRNA Discovery and Gene Regulation

    • Victor Ambros and Gary Ruvkun won the Nobel Prize in Physiology, or Medicine for their discovery of microRNA, small RNA regulators of gene expression in eukaryotes.
    • MicroRNAs play a crucial role in gene regulation posttranscription, a process that occurs before cellular machinery is activated for protein production.
    • Previously, gene regulation was limited to transcription factors, but microRNAs have shown that regulation occurs at a later stage in gene expression.
    • The discovery of another microRNA in a gene present in all organisms indicates that microRNA’s role in gene regulation extends beyond roundworms.
    • By 2001, microRNAs were abundant in invertebrates and vertebrates, suggesting that microRNA-mediated post-transcriptional regulation is a general regulatory function.
    • Dysregulated microRNA expression is associated with cancer, diabetes, and autoimmune diseases.
    • Dysregulated microRNAs affect the biological capabilities of cancer cells during tumor development.
    • Certain microRNAs can serve as potential biomarkers for human cancer diagnosis, prognosis, and therapeutic targets.
    • Disruption and dysfunction of microRNAs can initiate the production of autoantibodies and contribute to the pathogenesis of autoimmune diseases.

    Leave a Reply

    Your email address will not be published. Required fields are marked *

    This site uses Akismet to reduce spam. Learn how your comment data is processed.

     WBCS Foundation Course Classroom Online 2024 2025 WBCS Preliminary Exam Mock Test WBCS Main Exam Mock Test WBCS Main Language Bengali English Nepali Hindi Descriptive Paper